A few hours after the attack, the Syrian Army warned that there will be "dangerous repercussions", calling the airstrike an aggressive move that threatens the "security and stability in the region".
Israeli officials have, however, confirmed in the past that strikes inside Syria have targeted weapons shipments believed to be headed to the Lebanon-based militant group Hezbollah.
Since becoming actively involved in the Syrian Civil War in 2015, Russian Federation has worked closely with Iran in support of the regime of Syria's President Bashar al-Assad.
Over the past years, the Israeli military has carried out sporadic attacks against various targets across Syria in what Damascus views as an attempt to boost the Takfiri terror groups that have been taking heavy blows from the Syrian army and allied forces on the battle ground. According to the IDF, Hezbollah was following closely the preparations for the maneuvers, in which the IDF Northern Corps is training with multiple divisions operating in simulated combat situations.
A major precedent was exposed exactly a decade ago by an earlier Israeli attack, which destroyed a Syrian nuclear plant built by North Korea on September 7, 2007. The UN investigators said, "Government forces continue to use chemical weapons against civilians in areas controlled by the opposition".
The plant is known as the Scientific Studies Researchers Center, or Centre D'Etudes et de Recherches Scientifiques (CERS).
While the strike was in the framework of Israel's policy of preventing arms transfers to Hezbollah but "it's another level of interference", he added. Jerusalem has repeatedly said that while there is no interest by Israel to enter into Syria's seven year civil war, there are red lines that Jerusalem has set including the smuggling of sophisticated weaponry to Hezbollah and an Iranian presence on its borders.
Amidror added that the attack that Israel carried out was consistent with Israel's defensive posture regarding Syria and that the overnight attack marked "another level" of response.
In recent weeks, rhetoric has significantly sharpened as Israel's Prime Minister Benjamin Netanyahu has accused Iran of building sites to produce missiles in both Syria and Lebanon.
"Serious security threats to Israel are presented by armed organisations, a lot of them financed and aided by Iran", he said in a public address.